We are proud to offer you PROGLUMIDE a NEW 100% pure product with no fillers or
additives crafted entirely in The USA for The discriminating vitamin and supplement
connoisseur.

                                                  PROGLUMIDE                                    
We have taken a break from Kratom to focus on bringing you Some new and effective
supplements that will rock your world. The first is, Pure Proglumide also known as Milid,
Milide, Xilamide; Xylamide; Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (+-)-
Proglumide inhibits gastrointestinal motility and reduces gastric secretions. It acts as a
cholecystokinin antagonist,[1] which blocks both The CCKA and CCKB subtypes.[2] It was
used mainly in The treatment of stomach ulcers,[3][4] although it has now been largely
replaced by newer drugs for this application.

An interesting side effect of proglumide is that it enhances The analgesia produced by
opioid drugs,[5] and can prevent or even reverse The development of tolerance to opioid
drugs.[6][7] This can make it a useful adjuvant treatment to use alongside opioid drugs in
The treatment of chronic pain conditions such as cancer, where opioid analgesics may be
required for long periods and development of tolerance reduces clinical efficacy of these
drugs.[8][9]

Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its
analgesic effects.[10]

(This is NOT The lesser quality,  "Proglumetacin" also called Afloxan, Protaxon and Proxil)
Which is a non-steroidal anti-inflammatory which is a class of substances that can cause
horrendous side effects which can be extremely dangerous and include internal bleeding!
Our Proglumide is unadulterated and created here in The USA through a professional and
consistent source, for an interesting and often sought after product. We believe you will find
it a both satisfying and worth experiencing. You will find impeccable quality as well as a
helpful and informative staff here at Kratom Dragon.
^ Bunney BS, Chiodo LA, Freeman AS. Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the
central nervous system. Annals of the New York Academy of Sciences. 1985;448:345-51.
^ González-Puga C, García-Navarro A, Escames G, León J, López-Cantarero M, Ros E, Acuña-Castroviejo D. Selective CCK-A but not
CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. Journal of Pineal
Research. 2005 Oct;39(3):243-50. doi:10.1111/j.1600-079X.2005.00239.x PMID 16150104
^ Bergemann W, Consentius K, Braun HE, Hirschmann H, Marowski B, Munck A, Rehs HU, Stopik D, Wilke G. Duodenal ulcer -
multicenter double-blind study with proglumide. (German) Medizinische Klinik. 1981 Apr 10;76(8):226-9.
^ Tariq M, Parmar NS, Ageel AM. Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. Journal of
Pharmacology and Experimental Therapeutics. 1987 May;241(2):602-7.
^ McCleane GJ. The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine. Clinical Journal of Pain.
2003 May-Jun;19(3):200-1.
^ Watkins LR, Kinscheck IB, Mayer DJ. Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide.
Science. 1984 Apr 27;224(4647):395-6.
^ Tang J, Chou J, Iadarola M, Yang HY, Costa E. Proglumide prevents and curtails acute tolerance to morphine in rats.
Neuropharmacology. 1984 Jun;23(6):715-8.
^ Bernstein ZP, Yucht S, Battista E, Lema M, Spaulding MB. Proglumide as a morphine adjunct in cancer pain management. Journal of
Pain and Symptom Management. 1998 May;15(5):314-20.
^ McCleane GJ. The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign
pain. Anesthesia and Analgesia. 1998 Nov;87(5):1117-20.
^ Rezvani A, Stokes KB, Rhoads DL, Way EL. Proglumide exhibits delta opioid agonist properties. Alcohol and Drug Research.
1987;7(3):135-46.
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