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We are proud to offer you PROGLUMIDE. 100% pure product with no fillers or additives,
crafted  in The USA for The discriminating vitamin and supplement connoisseur. Be sure to
check our product page as we have many new and interesting
PRODUCTS
                                   
                                  PROGLUMIDE                                    
We have taken a break from Kratom to focus on bringing you Some new and effective supplements
that will rock your world. The first is, Pure Proglumide also known as Milid, Milide, Xilamide; Xylamide;
Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (+-)-

Proglumide inhibits gastrointestinal motility and reduces gastric secretions. It acts as a
cholecystokinin antagonist,[1] which blocks both The CCKA and CCKB subtypes.[2] It was used
mainly in The treatment of stomach ulcers,[3][4] although it has now been largely replaced by newer
drugs for this application.

An interesting side effect of proglumide is that it enhances The analgesia produced by opioid drugs,
[5] and can prevent or even reverse The development of tolerance to opioid drugs.[6][7] This can
make it a useful adjuvant treatment to use alongside opioid drugs in The treatment of chronic pain
conditions such as cancer, where opioid analgesics may be required for long periods and
development of tolerance reduces clinical efficacy of these drugs.[8][9]

Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic
effects.[10] This is NOT The lesser quality, "Proglumetacin" also called Afloxan, Protaxon and Proxil)
Which is a non-steroidal anti-inflammatory which is a class of substances that can cause horrendous
side effects which can be extremely dangerous and include internal bleeding! Our Proglumide is
unadulterated and created here in The USA through a professional and consistent source, for an
interesting and often sought after product. We believe you will find it a both satisfying and worth
experiencing. You will find impeccable quality as well as a helpful and informative staff here at Kratom
Dragon.
                      SUPER LOW COST SHIPPING, AS LOW AS
           $6.99 USD DOMESTIC & $16.99 USD INTERNATIONAL
^ Bunney BS, Chiodo LA, Freeman AS. Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous
system. Annals of the New York Academy of Sciences. 1985;448:345-51.
^ González-Puga C, García-Navarro A, Escames G, León J, López-Cantarero M, Ros E, Acuña-Castroviejo D. Selective CCK-A but not CCK-B receptor
antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. Journal of Pineal Research. 2005 Oct;39(3):243-50.
doi:10.1111/j.1600-079X.2005.00239.x PMID 16150104
^ Bergemann W, Consentius K, Braun HE, Hirschmann H, Marowski B, Munck A, Rehs HU, Stopik D, Wilke G. Duodenal ulcer - multicenter double-blind
study with proglumide. (German) Medizinische Klinik. 1981 Apr 10;76(8):226-9.
^ Tariq M, Parmar NS, Ageel AM. Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. Journal of Pharmacology and
Experimental Therapeutics. 1987 May;241(2):602-7.
^ McCleane GJ. The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine. Clinical Journal of Pain. 2003
May-Jun;19(3):200-1.
^ Watkins LR, Kinscheck IB, Mayer DJ. Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide. Science. 1984 Apr
27;224(4647):395-6.
^ Tang J, Chou J, Iadarola M, Yang HY, Costa E. Proglumide prevents and curtails acute tolerance to morphine in rats. Neuropharmacology. 1984
Jun;23(6):715-8.
^ Bernstein ZP, Yucht S, Battista E, Lema M, Spaulding MB. Proglumide as a morphine adjunct in cancer pain management. Journal of Pain and Symptom
Management. 1998 May;15(5):314-20.
^ McCleane GJ. The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain. Anesthesia
and Analgesia. 1998 Nov;87(5):1117-20.
^ Rezvani A, Stokes KB, Rhoads DL, Way EL. Proglumide exhibits delta opioid agonist properties. Alcohol and Drug Research. 1987;7(3):135-46.
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